| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 13-09-25 15:30 | Ajax Amsterdão | PEC Zwolle | 3:1 |
| 13-09-25 17:45 | NEC Nijmwegen | PSV Eindhoven | 3:5 |
| 13-09-25 18:10 | Go Ahead Eagles Deventer | FC Volendam | 3:0 |
| 13-09-25 20:00 | FC Twente Enschede | NAC Breda | 2:2 |
| 13-09-25 20:00 | Feyenoord Rotterdão | SC Heerenveen | 1:0 |
| 14-09-25 11:15 | Excelsior Roterdão | Sparta Roterdão | 0:1 |
| 14-09-25 13:30 | Heracles Almelo | AZ Alkmaar | 1:2 |
| 14-09-25 13:30 | FC Utrecht | FC Groningen | 0:1 |
| 14-09-25 15:45 | Telstar | Fortuna Sittard | 1:3 |